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National Drug Formulary
R

Recombinant Factor IX

Availability of ACE Drug Guidance

Yes

Biologics Drug Information Overview

Yes

Subsidy Information and Financing Scheme

Standard Drug List

Active ingredients: Coagulation Factor IX (Recombinant) | Recombinant Factor IX Synonyms: Albutrepenonacog Alfa [INN] | Nonacog Alfa [INN/USAN]

General information

Subsidy Information and Financing Scheme

[SDL] Recombinant factor IX (Nonacog alfa) [BeneFIX] Injection, 250 international units, 500 international units, 1,000 international units, 2,000 international units

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Drug Guidance for Subsidy

19/12/2022 Recombinant blood products for prophylaxis and management of haemophilia A and B>

[R] The Ministry of Health’s Drug Advisory Committee has recommended the following recombinant blood products for inclusion on the MOH Standard Drug List (SDL) for patients with haemophilia A (congenital factor VIII deficiency) and haemophilia B (congenital factor IX deficiency) in line with their registered indications when used as treatment and prophylaxis of bleeding episodes:

  • Octocog alfa (Advate) 250 international units, 500 international units, 1000 international units and 1500 international units powder and solvent for solution for injection

  • Rurioctocog alfa pegol (Adynovate) 250 international units, 500 international units, 1000 international units, 1500 international units, 2000 international units and 3000 international units powder and solvent for solution for injection

  • Nonacog alfa (BeneFIX) 250 international units, 500 international units, 1000 international units and 2000 international units powder and solvent for solution for injection

[NR] Blood products that have not been recommended for subsidy due to unacceptable cost-effectiveness compared with subsidised alternatives are listed in the Annex.

The subsidy class and subsidy implementation dates (if applicable) for all blood products included in the review are provided in the Annex.

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General Availability in Public Healthcare Institution

Note:

General availability information reflected is based on the Public Healthcare Institutions’ (PHI) formulary on what is commonly used for treating their patient population and may or may not be available for patients not under the care of that institution. It does not reflect the PHI’s actual inventory availability and is subjected to change. Please consult the Public Hospitals or Polyclinics for details on availability and supply restrictions/considerations. General availability is not tied to any brand unless otherwise stated.

Users are to consult the respective PHIs for actual inventory availability and supply restrictions/consideration

Availability information

Formulation

Public Healthcare Institution

BeneFIX Injection 500 international units

  1. KK Women's and Children's Hospital

  2. Khoo Teck Puat Hospital

  3. National University Hospital

List of monographs containing this active ingredient

Recombinant Factor IX [Idelvion]

Recombinant Factor IX [BeneFIX]

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