TRISEQUENS TABLET [SIN06011P]
Active ingredients: (BLUE TABLET) ESTRADIOL HEMIHYDRATE 2.07 MG EQUIVALENT TO | (RED TABLET) ESTRADIOL HEMIHYDRATE 1.03 MG EQUIVALENT TO | (WHITE TABLET) ESTRADIOL AS HEMIHYDRATE 2.07 MG EQUIVALENT TO + (WHITE TABLET) NORETHISTERONE ACETATE
Last updated on 9 October 2026
Product Info
TRISEQUENS TABLET
[SIN06011P]
Product information
Active Ingredient and Strength | (BLUE TABLET) ESTRADIOL HEMIHYDRATE 2.07 MG EQUIVALENT TO - 2 MG |
Dosage Form | TABLET, FILM COATED |
Manufacturer and Country | NOVO NORDISK A/S - DENMARK |
Registration Number | SIN06011P |
Licence Holder | NOVO NORDISK PHARMA (SINGAPORE) PTE LTD |
Forensic Classification | PRESCRIPTION ONLY MEDICINES |
Anatomical Therapeutic Chemical (ATC) code | G03FB05 |
Prescription-only Medicines with Exemptions for Supply without Prescription | NA |
Indication
4.1 Therapeutic indications
Hormone Replacement Therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women with at least 6 months since last menses.
Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis (see section 4.4 – please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information).
The experience of treating women older than 65 years is limited.
Dosing
4.2 Posology and method of administration
Trisequens® is a continuous sequential HRT product. The oestrogen is dosed continuously. The progestagen is added for 10 days of every 28-day cycle, in a sequential manner.
One tablet should be taken orally once a day without interruption, preferably at the same time of the day starting with oestrogen therapy (blue film-coated tablet) over 12 days, followed by 10 days of oestrogen/progestagen therapy (white film-coated tablet) and 6 days of oestrogen therapy (red film-coated tablet). A regular shedding of the endometrium is usually induced during the red tablet phase.
After intake of the last red tablet, treatment is continued with the first blue tablet of a new pack on the next day.
In women who are not taking HRT or women in transition from a continuous combined HRT product, treatment with Trisequens® may be started on any convenient day. In women in transition from another sequential HRT regimen, treatment should begin the day following completion of the preceding regimen.
For initiation and continuation of treatment of postmenopausal symptoms, the lowest effective dose for the shortest duration (see section 4.4 – please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information) should be used.
If the patient has forgotten to take a tablet, the tablet should be taken as soon as possible within the next 12 hours. If more than 12 hours have passed, the tablet should be discarded. Forgetting a dose may increase the likelihood of breakthrough bleeding and spotting.
Contraindications
4.3 Contraindications
Known, past or suspected breast cancer
Known, past or suspected oestrogen-dependent malignant tumours (e.g. endometrial cancer)
Undiagnosed genital bleeding
Untreated endometrial hyperplasia
Previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism)
Active or previous arterial thromboembolic disease (e.g. angina, myocardial infarction)
Known thrombophilic disorders (e.g. protein C, protein S or antithrombin deficiency (see section 4.4 – please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information))
Acute liver disease or a history of liver disease as long as liver function tests have failed to return to normal
Known hypersensitivity to the active substances or to any of the excipients
Porphyria.