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National Drug Formulary

CIROK TABLET 500 MG [SIN11576P]

Active ingredients: CIROK TABLET 500 MG

View product's general information
Last updated 24 April 2026

Product Info

CIROK TABLET 500 MG

[SIN11576P]

Product information

Active Ingredient and Strength

CIPROFLOXACIN - 500 MG

Dosage Form

TABLET, FILM COATED

Manufacturer and Country

KOREA UNITED PHARMACEUTICAL INC - KOREA, REPUBLIC OF

Registration Number

SIN11576P

Licence Holder

ZIWELL MEDICAL (S) PTE LTD

Forensic Classification

PRESCRIPTION ONLY MEDICINES

Anatomical Therapeutic Chemical (ATC) code

J01MA02

Prescription-only Medicines with Exemptions for Supply without Prescription

NA

Indication

INDICATIONS
CIROK is indicated for the treatment of infections.
Treatment of infections caused by the following microorganism; Escherichia coli, Shigella, Salmonella, Citrobacter, Klebsiella, Enterobacter, Serratia, Hafnia Proteus (Indole Positive and negative), Pseudomonas, Neisseria, Acinetobacter, Streptococcus, Clamydia, Staphylococcus, Corynebacterium, Clostridium, Bacteroides.
Infections: Respiratory infections; ear, nose and throat infections; mouth, tooth, genial inflammation, renal or urinary tract infections, genital infections including gonorrhea; gastrointestinal infections, biliation canal infections; bone and joint infections, soft tissue infections; gynecological and obstetrical infections, septicemia, meningitis, peritonitis, ophthalmic infections.

Dosing

1. DOSAGE AND ADMINISTRATION
The usual adult oral dosage of Ciprofloxacin hydrochloride (CIROK) for mild to moderate infections is 250~500 mg, twice a day. For more severe or complicated infections, a dosage of 750 mg may be given twice a day. For the treatment of acute infections, the usual duration is 5 to 10 days. Generally ciprofloxacin should be continued for at least 3 days after the signs and symptoms of infection have disappeared.

2. Impaired Renal Function
The following table provides dosage guidelines for use in patients with impaired renal function: monitoring of serum drug levels provides the most reliable basis for dosage adjustment.

Cirok Dosage Table 1



When only the serum creatinine concentration is known, the following formula may be used to estimate creatinine clearance.

  • Men :



Cirok Dosage Formula 1

  • Women : 0.85 X the value calculated for men.

In patients with severe infections and severe renal impairment, a unit dose of 750 mg may be administered at the intervals noted above; however, patients should be carefully monitored and the serum ciprofloxacin concentration should be measured periodically. Peak concentrations (1–2 hours after dosing) should generally range from 2 to 4 mcg/mL.
3. The determination of dosage for any particular patient must take into consideration the severity and nature of the infection.

Contraindications

2. The drug is contraindicated in the following patient
Patients with a history of hypersensitivity to ciprofloxacin.
Pregnant women and nursing mothers.
Infants and children.
Patients with epilepsy.
Patients who have a history of rupture and inflammation of tendon, hypersensitivity related to quinolone antibacterials.