AVORAX TABLET 400 MG [SIN09335P]

Product Info

AVORAX TABLET 400 MG

[SIN09335P]

Indication

Indications
Avorax is indicated in the systemic treatment of varicella zoster, chicken pox and herpes simplex (type 1 & 2) infections, including initial and recurrent. It is also used in the immunocompromised for prevention of recurrence and prophylaxis.

Dosing

Dosage and Administration
To be administered orally.

Dosage in adults:
For treatment of herpes simplex infections:
200mg should be taken 5 times daily at approximately four hourly intervals for 5 to 10 days. In severely immunocompromised patients (e.g. after marrow transplant) or in patients with impaired absorption from the gut, the dose can be doubled to 400mg.
Dosing should begin as early as possible after the start of an infection; for recurrent episode this should preferably be during the prodromal period or when the lesions first appear.

For suppression of recurrent herpes simplex in the immunocompetent patients:
Starting dose of 200mg should be taken four times daily at approximately six-hourly intervals. Many patients may be conveniently managed on a regimen of 400mg, twice daily at approximately 12-hourly intervals. Dosage titration down to 200mg 2 or 3 times daily may prove effective. Some patients may experience break-through infections on total daily doses of 800mg. Therapy should be interrupted periodically at intervals of 6 to 12 months, in order to reassess suitability for continued suppression.

For prophylaxis of herpes simplex infections in the immunocompromised patients:
200mg should be taken FOUR times daily at approximately six hourly intervals.
In severely immunocompromised patients (e.g. after marrow transplant) or in patients with impaired absorption from the gut, the dose can be doubled to 400mg or alternatively, intravenous dosing could be considered. The duration of prophylactic administration is determined by the duration of the period at risk.

For treatment of herpes zoster (shingles):
800mg 5 times daily for 7 – 10 days.

Dosage in children:
For treatment of herpes simplex infections and for prophylaxis of herpes simplex infections in the immunocompromised patients:
Children over the age of 2 years should be given adult dosages and children below the age of 2 years should be given half the adult dose. No specific data are available on the suppression of herpes simplex infections in immunocompetent children.

For treatment of varicella infections (chickenpox):
Children 2–12 years: 20mg/kg four times daily (up to a maximum of 800mg per dose) for 5 days.
Children 13–18 years: 800mg four times daily for 5 days.

Dosage adjustment in Renal Impairment:
For patient with a creatinine level of less than 10 ml per minute, oral dose need to be reduced to 200mg every 12 hours for herpes simplex and 800mg every 12 hours for varicella-zoster infections. Dose reduction might also be required in the elderly.

Contraindications

Contraindications
It is contraindicated in patients with known hypersensitivity to Acyclovir.