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National Drug Formulary

VALOVIR 500 VALACYCLOVIR TABLETS 500 MG [SIN14878P]

Active ingredients: VALACICLOVIR HYDROCHLORIDE 556 MG EQV VALACICLOVIR

View product's general information
Last updated on 9 October 2026

Product Info

VALOVIR 500 VALACYCLOVIR TABLETS 500 MG

[SIN14878P]

Product information

Active Ingredient and Strength

VALACICLOVIR HYDROCHLORIDE 556 MG EQV VALACICLOVIR - 500 MG

Dosage Form

TABLET

Manufacturer and Country

HETERO LABS LIMITED - INDIA

Registration Number

SIN14878P

Licence Holder

MEDICELL PHARMACEUTICAL (S) PTE. LTD.

Forensic Classification

PRESCRIPTION ONLY MEDICINES

Anatomical Therapeutic Chemical (ATC) code

J05AB11

Prescription-only Medicines with Exemptions for Supply without Prescription

NA

Indication

INDICATIONS
Treatment of shingles (herpes zoster) infection.

Herpes simplex infections of the skin and mucous membranes, including initial and recurrent genital herpes.

Prophylaxis of recurrent herpes simplex infections of the skin and mucous membranes, including genital herpes.

Dosing

DOSAGE AND ADMINISTRATION
Treatment of shingles (herpes zoster)

The dosage in adults is 1000 mg three times a day for 7 days.

Treatment of herpes simplex infections
The dosage in adults is 500 mg of Valacyclovir twice daily.

For recurrent infections, treatment should be maintained for 5 days. For initial episodes, which can be more severe, treatment may have to be extended to 10 days. Dosing should begin as early as possible. For recurrent episodes of herpes simplex, this should ideally be during the prodromal period or as soon as the first signs appear.

Prophylaxis of recurrences of herpes simplex infections

Immunocompetent patients should take 500 mg of Valacyclovir once daily.

For immunocompromised adult patients the dose is 500 mg twice daily.

There are no data on the reduction of transmission in other patient populations.

• Children
There are no data available on the use of Valaciclovir in children.

• Elderly
The possibility of renal impairment in the elderly must be considered and the dosage should be adjusted accordingly (see Renal impairment below).

Adequate hydration should be maintained.

• Renal impairment
Caution is advised when administering valaciclovir to patients with impaired renal function. Adequate hydration should be maintained.

The dosage of Valaciclovir should be reduced in patients with impaired renal function as shown in the table below:

Valovir Dosage Table 1



In patients on intermittent haemodialysis, the Valaciclovir dosage should be administered after the haemodialysis has been performed.

The creatinine clearance should be monitored frequently, especially during periods when renal function is changing rapidly, the Valaciclovir dosage should be adjusted accordingly.

Hepatic impairment
Studies with a 1 g unit dose of Valaciclovir show that dose modification is not required in patients with mild or moderate cirrhosis (hepatic synthetic function maintained).

Pharmacokinetic data in patients with advanced cirrhosis, (impaired hepatic synthetic function and evidence of portal-systemic shunting) do not indicate the need for dosage adjustment; however, clinical experience is limited. For higher doses (4 g or more/day), see Warnings and Precautions – please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information.

Contraindications

CONTRAINDICATIONS
Hypersensitivity to Valacyclovir, acyclovir or any of the excipients.