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National Drug Formulary

MESNA STADA® CONCENTRATE SOLUTION FOR INJECTION 400MG/4ML [SIN14991P]

Active ingredients: MESNA

View product's general information
Last updated on 9 October 2026

Product Info

MESNA STADA® CONCENTRATE SOLUTION FOR INJECTION 400MG/4ML

[SIN14991P]

Product information

Active Ingredient and Strength

MESNA - 400 MG/4 ML

Dosage Form

INJECTION, SOLUTION, CONCENTRATE

Manufacturer and Country

HAUPT PHARMA WOLFRATSHAUSEN GMBH - GERMANY

Registration Number

SIN14991P

Licence Holder

DCH AURIGA SINGAPORE

Forensic Classification

PRESCRIPTION ONLY MEDICINES

Anatomical Therapeutic Chemical (ATC) code

V03AF01

Prescription-only Medicines with Exemptions for Supply without Prescription

NA

Indication

Therapeutic indications

Prevention of urinary tract toxicity of oxazaphosphorines (e.g., ifosfamide, cyclophosphamide or trofosfamide).

In the case of a tumour therapy with ifosfamide MESNA Stada must always be given. In the case of a tumour therapy with cyclophosphamide or trofosfamide, MESNA Stada must always be given when dosages above 10 mg/kg are used and in patients at risk. Risks are in particular: previous radiation therapy in the area of the true pelvis, cystitis following previous therapy with ifosfamide, cyclophosphamide or trofosfamide and a history of uropathy.

Dosing

Posology and method of administration

IV: Unless prescribed otherwise, MESNA Stada is normally administered intravenously to adults at a dose of 20% of the oxazaphosphorine dose at time zero (the time of administration of the oxazaphosphorine), and then at 4 and 8 hours.

MesnaStada Dosage Table 1



Clinical experience with children has shown that it is beneficial in individual cases to give MESNA Stada at shorter intervals (e.g., every 3 hrs, total MESNA Stada dose = 60% of oxazaphosphorine dose). With very high-dose oxazaphosphorine cytostatic therapy (e.g., before bone marrow transplantation), the total MESNA Stada dose can be increased to between 120% and 160% of the oxazaphosphorine dose. It is recommended that after administration of 20% MESNA Stada (related to the total dose of oxazaphosphorine) at time 0, the remaining calculated dose should be given continuously IV over a period of 24 hrs with a perfusor. Alternatively, an intermittent bolus injection is possible: For adults 3 x 40% (at times 0, 4, 8 hrs) or 4 x 40% (at times 0, 3, 6, 9 hrs), respectively. For children due to more frequent micturition, the bolus injections should always be given in 3-hr intervals (e.g., 20% at times 0, 1, 3, 6, 9, 12 hrs). Instead of a bolus injection, short infusions of 15-min duration are possible. With a continuous infusion of ifosfamide (Holoxan), it has been shown to be of benefit to give MESNA Stada at time zero following the initial 20% bolus injection (start of infusion, time 0), followed by infusion to up to 100% of the ifosfamide dose, and to continue uroprotection for a further 6 to 12 hours after termination of the ifosfamide infusion.

MesnaStada Dosage Table 2



Contraindications

Contraindications

Known hypersensitivity to mesna, other thiol compounds or to any of the excipients.

As mesna is only indicated in combination with oxazaphosphorines, the contraindications which apply to cyclophosphamide, ifosfamide and trofosfamide should also be observed.