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National Drug Formulary

SONAZOID POWDER AND SOLVENT FOR DISPERSION FOR INJECTION 16 MICROLITRE PER VIAL [SIN16077P]

Active ingredients: PERFLUOROBUTANE MICROBUBBLES

View product's general information
Last updated on 9 October 2026

Product Info

SONAZOID POWDER AND SOLVENT FOR DISPERSION FOR INJECTION 16 MICROLITRE PER VIAL

[SIN16077P]

Product information

Active Ingredient and Strength

PERFLUOROBUTANE MICROBUBBLES - 16 ΜICROLITRE

Dosage Form

INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION

Manufacturer and Country

GE HEALTHCARE AS (OSLO SITE) - NORWAY
B. BRAUN MELSUNGEN AG (SOLVENT) - GERMANY

Registration Number

SIN16077P

Licence Holder

GE HEALTHCARE PTE. LTD.

Forensic Classification

PRESCRIPTION ONLY MEDICINES

Anatomical Therapeutic Chemical (ATC) code

V08DA06

Prescription-only Medicines with Exemptions for Supply without Prescription

NA

Indication

Therapeutic indications

This medicinal product is for diagnostic use only.

Sonazoid is an ultrasound contrast agent for use in vascular phase and Kupffer phase for ultrasonic imaging of focal hepatic lesions.

Dosing

Posology and method of administration

Posology
This medicinal product should always be given by a physician or other qualified health personnel.

The usual adult dosage is up to one vial of the product containing 16 microlitre of perfluorobutane (PFB) microbubbles (MB) suspended in 2 ml of the accompanying sterile water for reconstitution to make a 8 microlitre/ml suspension. The product is for intravenous use only and the usual dosage is as per the table below.

The recommended clinical dose is 0.12 microlitre PFB microbubbles/kg body weight (is equivalent to 0.015 ml/kg as a suspension).

Refer to the table below for weight-based dosages.

Sonazoid Dosage Table 1



Use in elderly
The usual/proposed dose for adults can be used.

Paediatric use
The safety of this product has not been established in the paediatric population (no data are available).

Method of administration
Before administering Sonazoid, see Special precautions for disposal and other handling for instructions for reconstitution and use – please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information.

The reconstituted product is for intravenous use. No special preparation of the patient is required. Ultrasound imaging must be performed during injection of Sonazoid as optimal contrast effect is obtained immediately after administration. The intravenous line must be flushed immediately with 5–10 ml sodium chloride 0.9% solution for injection to ensure complete administration of the contrast agent.

Contraindications

Contraindications

Hypersensitivity to the active substance or to any of the excipients.