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National Drug Formulary

XYLOCREAM 5% W/W [SIN17501P]

Active ingredients: LIDOCAINE | PRILOCAINE

View product's general information
Last updated on 9 October 2026

Product Info

XYLOCREAM 5% W/W

[SIN17501P]

Product information

Active Ingredient and Strength

LIDOCAINE - 2.5% W/W
PRILOCAINE - 2.5% W/W

Dosage Form

CREAM

Manufacturer and Country

RAFARM S.A. - GREECE

Registration Number

SIN17501P

Licence Holder

GOLDPLUS UNIVERSAL PTE LTD

Forensic Classification

PHARMACY ONLY MEDICINES

Anatomical Therapeutic Chemical (ATC) code

N01BB20

Prescription-only Medicines with Exemptions for Supply without Prescription

NA

Indication

Therapeutic indication

  • Surface anaesthesia of the skin in connection with needle insertion and for superficial surgical procedures.

  • Surface anaesthesia of leg ulcers prior to cleaning and superficial surgical procedures, for example removal of fibrin, pus and necroses.

  • Surface anaesthesia of the genital mucosa.

Dosing

Posology and method of administration

Adults

Intact skin:

Xylocream Dosage Table 1



Leg ulcers:

For cleaning of leg ulcers: approx. 1–2 g per 10 cm2. The cream is applied in a thick layer to the surface of the ulcer, but not more than 10 g per treatment procedure. Cover the surface of the ulcer with an occlusive dressing. An opened tube is intended for a single use, and any remaining cream must therefore be discarded after each treatment procedure.

Application time: at least 30 minutes.

For leg ulcers with tissue that is particularly difficult to penetrate the application time may be extended to 60 minutes. Cleaning of the ulcer should begin within 10 minutes after the cream has been removed.

Lidocaine/prilocaine has been used for up to 15 treatment procedures over a period of 1–2 months without a decline in effect or an increase in the number of local reactions.

Genital use

Skin:

Use prior to injection of local anaesthetics:

Men: 1 g per 10 cm2. A thick layer of cream is applied to the skin. Application time: 15 minutes.

Women: 1–2 g per 10 cm2. A thick layer of cream is applied to the skin. Application time: 60 minutes.

Genital mucosa:

For removal of condyloma or prior to injection of local anaesthetics: approx. 5–10 g, depending on the area to be treated. The whole surface, including the mucosal folds, must be covered. Occlusion is not necessary.

Application time: 5–10 minutes. The surgery must be begun immediately after removal of the cream.

Children

For needle insertion, curettage of the lesions caused by mollusca contagiosa and other minor surgical procedures:

1 g per 10 cm2.

A thick layer of cream is applied to the skin and covered with an occlusive dressing. The dose should not exceed 1 gram per 10 cm2 and must be adjusted according to the application area:

Xylocream Dosage Table 2



After a longer application time, the anaesthesia decreases.

Children with atopic dermatitis: reduce application time to 30 minutes.

Contraindications

Contraindications

Known hypersensitivity to local anaesthetics of the amide type or to any of the excipients. Lidocaine/prilocaine must not be used in premature infants (born before week 37 of pregnancy).